Prevalence of Helicobacter pylori Infection Among Dyspeptic Patients at Federal Medical Centre, Keffi, Nasarawa State

Helicobacter pylori infection is a causative factor in peptic ulcer disease and gastric malignancy, and its prevalence in Nigerian populations remains high due to poor sanitation, crowded living conditions, and limited eradication programmes. This study investigates the prevalence of Helicobacter pylori infection among patients presenting with dyspepsia at the Federal Medical Centre, Keffi, Nasarawa State, in the North Central zone. A cross-sectional design is applied to 280 consecutive dyspeptic patients presenting to the gastroenterology unit over a six-month period. Diagnostic testing employs the stool antigen assay as the primary non-invasive detection method, supplemented by histological assessment of endoscopic biopsies in patients undergoing upper gastrointestinal endoscopy. Structured questionnaires capture sociodemographic data, symptom duration, dietary habits, water source, and prior antibiotic exposure. SPSS is used for analysis, with logistic regression identifying predictors of infection. Available regional literature from North Central Nigeria reports H. pylori prevalence ranging from 55 to 75 percent among dyspeptic patients, with pit latrine use and household crowding as significant correlates. The Maastricht V/Florence Consensus Report guidelines provide the diagnostic and management reference framework. Findings will inform the unit on eradication treatment strategy and public health messaging for dyspepsia management. Keywords: Helicobacter pylori, dyspepsia, prevalence, Nasarawa State, North Central Nigeria.