Oxidative Stress Biomarkers in Adult Residents Living Near Refuse Dumpsites in Ogun State, South West Nigeria

Background: Open refuse dumpsites are endemic across Nigerian states, releasing toxic leachates and gaseous pollutants that may induce systemic oxidative stress in nearby residents. The physiological burden of prolonged dumpsite proximity has received limited empirical attention in the South West geopolitical zone outside Lagos. Objectives: This study seeks to measure malondialdehyde as a lipid peroxidation marker, superoxide dismutase, and catalase activities in adult residents living within 200 metres of refuse dumpsites in Ogun State and to compare these values with controls residing at least two kilometres away. Methods: Sixty residents near dumpsites and thirty controls will be recruited. Five millilitres of venous blood will be collected for assay of oxidative stress markers using spectrophotometric methods. A structured questionnaire will capture residential duration, health complaints, and dietary antioxidant intake. Independent t-tests and correlation analysis will be applied. Expected Outcomes: Dumpsite-proximate residents are anticipated to exhibit elevated malondialdehyde and reduced antioxidant enzyme activities, indicating significant oxidative stress burden. Conclusion: Results will advocate for improved waste management policy and community health monitoring in peri-urban Ogun State communities. Keywords: oxidative stress, malondialdehyde, refuse dumpsite, antioxidants, Ogun State.