Hepatitis B Surface Antigen Prevalence and Liver Biochemistry in Commercial Drivers in Ebonyi State

Commercial drivers represent a high-risk group for blood-borne viral infections and hepatic dysfunction due to their lifestyle characteristics including risk-taking behaviours and limited access to healthcare. This study evaluates hepatitis B surface antigen prevalence and liver biochemical parameters including alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase in commercial drivers in Ebonyi State, South East Nigeria. A cross-sectional design was used, recruiting 200 commercial bus and motorcycle drivers from major motor parks. Hepatitis B surface antigen was detected using a validated rapid immunochromatographic strip test and confirmed by ELISA. Venous blood samples were also collected for liver function testing. History of blood transfusion, scarification, shared razors use, and alcohol consumption was obtained through structured interviews. Vaccination history against hepatitis B was documented for all participants. The study aims to determine the burden of HBsAg carriage and its relationship to biochemical evidence of hepatic injury in this occupational group. Chi-square tests and binary logistic regression will identify sociodemographic predictors of HBsAg positivity. Findings will inform targeted hepatitis B vaccination campaigns and health education in transport corridors across South East Nigeria. Keywords: hepatitis B surface antigen, liver enzymes, commercial drivers, HBsAg, Ebonyi State.