Assessment of Knowledge and Compliance with Infection Control Among Nurses at Niger Delta University Teaching Hospital, Bayelsa State

Background: Infection control compliance among nurses in South South Nigerian hospitals is critical for preventing healthcare-associated infections in a region with limited isolation infrastructure. Aim: This study assessed nurses' knowledge and compliance with infection control measures at Niger Delta University Teaching Hospital, Bayelsa State. Methods: A descriptive cross-sectional design recruited 90 registered nurses through stratified random sampling. Data collection used a validated knowledge questionnaire and a structured observation checklist. SPSS version 25 was used for analysis. Results: Knowledge was adequate in 66% of participants, while full compliance with recommended infection control measures, including use of personal protective equipment, waste segregation, and aseptic technique, was observed in only 48%. Nurses in intensive care and surgical wards demonstrated higher compliance rates. Significant associations existed between refresher training attendance and compliance levels. Conclusion: The knowledge-practice gap in infection control underscores the need for reinforcement strategies. Continuous quality improvement programmes, regular infection control audits, and provision of adequate protective equipment are recommended. Keywords: infection control, compliance, nursing, Bayelsa, healthcare-associated infections.