Effect of Chronic Alcohol Consumption on Liver Function Biomarkers Among Male Adults in Uyo, Akwa Ibom State

Excessive alcohol consumption is a well-established hepatotoxic factor and continues to represent a significant public health concern in many Nigerian communities. This study assessed the effect of chronic alcohol consumption on liver function biomarkers among male adults in Uyo, Akwa Ibom State, South South Nigeria. Ninety male participants were recruited from community-based settings, comprising 60 self-reported chronic drinkers and 30 age-matched non-drinkers. Blood samples were collected and analysed for serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin. Alcohol consumption history, duration, and quantity were assessed using the Alcohol Use Disorders Identification Test. Chi-square and Mann-Whitney U tests were applied for group comparisons. Results revealed significantly elevated liver enzyme levels in chronic drinkers compared to non-drinkers, with alanine aminotransferase and aspartate aminotransferase most markedly elevated. Heavier drinkers showed the highest enzyme derangements, consistent with dose-dependent hepatotoxicity. Elevated bilirubin was detected in 28 percent of chronic drinkers, suggesting beginning cholestatic injury. The study concludes that chronic alcohol intake is associated with measurable hepatocellular damage in this male population. Early hepatic surveillance, community-based alcohol harm reduction strategies, and accessible de-addiction services are strongly advocated for Uyo and similar high-consumption communities. Keywords: alcohol consumption, liver function, aminotransferase, hepatotoxicity, Akwa Ibom.